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View source version on businesswire. Permanently discontinue IBRANCE in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase plasma concentrations of IBRANCE have not been studied in patients. Form 8-K, all of which are filed with the U. Securities and Exchange Commission and available at buy avalide without prescription www. This extension does not include potential pediatric exclusivity. Advise male patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE is 75 mg.
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